Friday, 13 May 2016

Death of birds sparks off bird flu scare

  • SPECIAL CORRESPONDENT
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Birds aged between three weeks and 70 weeks were dying and the owners thought it was due to heat stroke.
File Photo
Birds aged between three weeks and 70 weeks were dying and the owners thought it was due to heat stroke.

The death of around 10,000 birds in a poultry farm in Humnabad taluk has sparked off fears of a bird flu break out in Bidar district.
Deputy Commissioner Anurag Tewari held a meeting of officials on Saturday and Sunday regarding the issue.
Officials informed that between 600-1,000 young chicken died in a private poultry near Humnabad in the last two weeks. Birds aged 3-70 weeks died and the owners thought that it was due to heat stroke. However, Pramod Kulkarni, assistant director of animal husbandry, noticed the odd phenomenon and informed senior officers. A team of surveillance officers led by Shiva Murthy visited the farm and sent samples of body tissues to a laboratory in Bengaluru. A team of the central animal husbandry department officials is expected to visit the Humnabad farm and surrounding farms on Monday, veterinary officials said.
“We are not coming to any conclusions now. We will await test results,” the DC said. He said officers of the concerned departments of state and central government would be kept informed. “We will follow their instructions,” he said.

New paper-based system to quickly detect Zika virus

  • PTI
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If the sample contains the RNA of the Zika virus, the test area turns purple.

Scientists have developed a revolutionary paper-based sensor system for detecting the Zika virus within an hour, an advance that could help fight the disease that has been linked to serious birth defects.
Employing toehold sensors and isothermal RNA amplification, researchers, including those from Harvard University and Massachusetts Institute of Technology (MIT) in U.S. created diagnostic sensors on a freeze-dried piece of paper the size of a stamp.
Activated by the amplified sample, the diagnostic sensors programmed into this paper provide extremely sensitive, low-cost, programmable diagnostics that provide rapid results.
Currently, reliable diagnosis for patients suspected of the Zika virus involves nucleic acid-based testing, which is dependent on laboratory access, highly specific and expensive equipment, and trained technicians.
As a result, this type of testing is unsuitable and unavailable in remote locations where surveillance and containment are critically needed.
This new technology, on the other hand, is easy to use and requires little to no training. Specifically tuned to the Zika virus, sensors are applied to small paper samples.
Using a small saliva, urine, or blood sample, equivalent to the amount required by blood glucose monitors to test blood sugar levels, the sample is applied to the sensors, triggering a response that provides visually evident results in as little as an hour.
If the sample contains the RNA of the Zika virus, the test area turns purple.
In making such a simple to use test, the team has created a exciting tool that promises to bring portable, reliable, and inexpensive Zika diagnostics to the field at less than a dollar per test.
Moreover, it does not require a lab, expensive equipment, or highly-trained technicians to administer.
“The diagnostic platform developed by our team has provided a high-performing, low-cost tool that can work in remote locations,” said lead author Keith Pardee, assistant professor from University of Toronto.
“We have developed a workflow that combines molecular tools to provide diagnostics that can be read out on a piece of paper no larger than a postage stamp,” said Mr. Pardee.
“Our synthetic biology pipeline for rapid sensor design and prototyping has tremendous potential for application for the Zika virus and other public health threats, enabling us to rapidly develop new diagnostics when and where they are needed most,” he said.
The study was published in the journal Cell.

After drug stock-outs, shortage of condoms now hits fight against AIDS

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Worse, in States like Maharashtra, they are dispatched via snail mail to districts

After a series of drug stock-outs, India’s national AIDS programme is now nearly out of condoms. To make things worse, people living with HIV (PLHIVs) are battling red tape in States like Maharashtra, where the government dispatched the condoms via snail mail, to be delivered in alphabetical order to districts.
Given the situation, commercial sex workers in high-burden districts like Sangli, (which has the highest incidence of HIV in Maharashtra after Mumbai) are now dependent on condom donations.
Alphabetical order
“We approached NACO and they agreed that there is a crisis. Instead of showing urgency, they put packets of 4500 condoms — which is way too little for us anyway — in post. To add to the problems, for the last two years, the State AIDS society has been dispatching condoms via snail mail, alphabetically. By the time, Sangli’s turn comes, a lot of our commercial sex workers would have exposed themselves,” said Meena Seshu of the National Network of Sex Workers (NNSW) who runs SANGRAM, a grassroots health and human rights NGO for sex workers.
“What is the point of counselling people coming into our offices, if we cannot help them with something as fundamental as a condom?” Ms. Seshu asked.
The government’s response is that the guidelines specify that India Post be used to dispatch condoms. “At the review meeting of all project directors held at NACO on April 28, we were told to speed up supplies. So we can now use private firms to dispatch condoms. As per procedure, we have to send the stock in alphabetical order and since there was no pending demand for condoms, we went by the system.
We have been following this system from the beginning, but now it [the dispatch of condom boxes] will be based on priority,” said Mukund Diggikar, additional project director, Maharashtra State Aids Control Society.
Less than a month’s supply
The Indian government has been providing free condoms under its community-based AIDS prevention programme for high-risk groups like commercial sex workers. While the shortage is country-wide, according to National AIDS Control Organisation’s (NACO) weekly stock update on April 23, Andhra Pradesh, Delhi, Madhya Pradesh, Manipur, Punjab, Rajasthan and Sikkim are the worst affected, with less than a month’s supply. The norm is to keep a buffer stock of six months — so that sporadic stock-outs can be met. Not a single State in India, barring Haryana, has stocks worth six months.
“Frankly, we are out of money. There are any solutions to offer. In Sangli’s case, we are aware of the distribution problems. Somehow, we have not been able to sort that out.
The system of sending condoms by post is not new. The rest of Maharashtra is not as bad as Sangli. We have told them that they can go and collect it from the post offices,” the official added.
Sangli district alone requires 75,000 condoms each month. For now, humanitarian aid organisation MSF has offered to donate a month’s supply to SANGRAM, said Ms. Seshu.
Short of kits too
While the United Nations is setting ambitious goals of ending the AIDS epidemic by 2030, India is also struggling with shortage of critical antiretroviral drugs, particularly Zidovudine and Lamivudine (ZL), and viral load testing kits across the country. As a part of the government’s intervention, NACO provides 15 free ARV drugs used in first line, second line and paediatrics combination regimen.
In the case of adult dosage of ZL, the national consumption was 24,34,914 in March 2016, leaving a balance of 13,10,672 on April 21 — just enough for 15 more days. Which means, as of this week, the national programme is entirely stocked-out.
The shortage in the national programme is putting patients at the risk of developing drug resistance.

Food in India untested for diabetes-linked chemical

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Alloxan is used in laboratories to induce diabetes in rats

Alloxan, a chemical allegedly used in the manufacture of refined flour, faced the prospect of limitations on its use after a litigant approached the Madras High Court to request a ban on the mixing of alloxan in white flour. Alloxan is used in laboratories to induce diabetes in rats and to test the efficacy of anti-diabetic medicines but no tests have been scientifically done to detect its presence in India.
Increased risk
Global health literature suggests that its presence in flour implies that consumers of popular Indian food such as parathas and puris are at increased risk of diabetes as well as heart disease.
In a 2013 report The Hindu quoted several Madurai-based cardiologists who suggested that alloxan and other agents in flour may be associated with heart disease.
Alloxan has been banned by the Food Safety and Standards Authority of India (FSSAI), the Delhi-based central body that has the final say on what additives are permissible in food.
Independent food testing labs in Delhi say that they have yet to detect the presence of the substance. “So far we haven’t noted alloxan in our tests,” said Sunil S., a food chemist at the Shriram Institute of Industrial Research.
Alloxan’s chemical existence has been known since the 19th century, when it was discovered in human excretions, indicating that it could be synthesised in the body.
Alloxan’s structure mimics that of glucose, which allows it to be absorbed by the pancreas and once inside the organ, it destroys insulin-producing beta cells.
However, according to the American Chemical Society, it cannot be taken up by the human pancreas, though it has been shown to be associated with liver and kidney toxicity.
No known studies have yet specifically discovered alloxan in Indian foods. However other bleaching agents that are used to make flour white, such as benzoyl peroxide and chlorine oxide — and also named in the petition before the Madras High Court — are permitted by the FSSAI provided they appear below specified limits, according to a notification on the agency’s website.
There have been no studies that examine the issue of alloxan in street food, said an official with Delhi’s Food Safety department, who did not want to be identified. The United States Food and Drugs Administration has also not issued specific notifications on alloxan.

15-year-old boy suffering from progeria passes away

  • PTI
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When Nihal met his idol, Aamir Khan. Photo courtesy: Facebook/Team Nihal
When Nihal met his idol, Aamir Khan. Photo courtesy: Facebook/Team Nihal

He had become the face of a campaign against the rare genetic disorder in the country.

A 15-year-old Nihal Batla, who was suffering from progeria and had become the face of a campaign against the rare genetic disorder in the country, died on Monday.
Nihal, from Bhiwandi in adjoining Thane district, was fighting the disease that aged him eight times faster than normal.
He was at his grandparents’ house at Karimnagar in Telangana to attend a family wedding. On Monday evening, he felt dehydrated due to the scorching heat and had to be rushed to a private hospital for treatment.
Within a few hours, he passed away, family sources said.
His last rites were performed in Karimnagar on Tuesday.
Nihal and his family had taken up the challenge of raising awareness about the incurable disease, which has an incidence of one in four million, and of finding more such cases for medical intervention in the country.
The boy, who was part of a clinical trial for Lonafarnib drug in Boston to test if the drug could delay ageing, had posted his pictures on Facebook and Twitter to reach out to parents, specially in rural areas.
Progeria or Hutchinson-Gilford Progeria syndrome, from which Nihal suffered, causes accelerated ageing in children, leading to premature death mostly due to heart attacks.
Keywords: ProgeriaNihal Batla